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During the time when Isu members were desperately trying to find a solution to save the world from the cataclysm or to withstand it. One of the solution was to transfer the consciousness of Isu members to a stronger vessel/body which can withstand the harsh environment caused by the cataclysm. A process where one’s consciousness would be transferred to a machine and then a stronger vessel, with humans used as test subjects.

The first volunteer for the experiment was Juno’s own husband, Aita. He managed to successfully transfer himself into the stronger body, but in the process, his mind deteriorated, rendering him catatonic and unstable.

For months, he begged Juno to end his life. Until she eventually complied, under the condition that she uses his genetic code for a plan which she devised following her imprisonment into the Grand Temple.

She took his DNA code and transferred it to human subject who would carry it over generation, reincarnating him over and over, creating what is known as “A Sage”. The cycle of Sages continues to this day, where a person is born, bearing the genetic code of Aita, which eventually takes over the host’s consciousness to become Aita himself, with Aita’s original memories infusing within the Sage’s mind and whose personality fades and dominates at different points and situations.

Sages are distinguished with their Heterochromia, where each eye bears a different color than the other, or sometimes more than one color in the same iris.

These signs and distinctive characteristics vary from one Sage to another.

It must also be noted that Sages can appear at any point in history and two sages can still be born in the same era, even when both are still alive.

Creation of Mankind

The Isu are responsible for the creation of the human race. They’ve created Homo sapiens, designing them in their own likeness and image, yet stripped of their sixth sense and other characteristics, to insure they remain an inferior species and a docile workforce.

They also created Homo neanderthalensis. Unlike Homo sapiens, those were made as a military or an expeditionary force.

Pieces of Eden

The Pieces of Eden are high tech ancient artifacts that vary in their shape, size and purpose. They are often known to exhibit miraculous abilities comparable to magic. However, they’re not magic, but scientific devices which is far beyond our technological advancement level. Some of them are used as weapons, such as The Swords of Eden, others have controlling abilities like The Apples of Eden, while The Shrouds of Eden posses the ability to heal and even raise from the dead.

It is also known that Pieces of Eden can be used in conjunction with other P.O.E such as The Staff of Eden with The Apple, or the Koh-i-Noor diamond which, according to Durga, an Isu member can connect multiple P.O.E. together, for a purpose yet unknown.

Some of P.O.E. do not have one purpose or effect, that even The Isu themselves discovered their new purposes by chance, such as The Apple, which was discovered to have the ability to create things based on the collective thoughts of a group of people enthralled by its beam.

Shay Cormac discovered a different type of Pieces of Eden in Lisbon which had the ability to control seismic activity.

Abstergo Industries, along with Clay Kaczmarek, thoroughly studied history through genetic memory experiments in the Animus and have discovered that most legends and myths told throughout history are actually truly, with the part that is related to magic being actually an effect of one or more of the Pieces of Eden.